Joao Sousa and Benoit Paire fall at the first hurdle in Croatia
Joao Sousa and Benoit Paire were early casualties at the Croatia Open in Umag.
The seventh-seeded Sousa, who won his home title the Estoril Open back in May, was beaten by world No 81 Aljaz Bedene, with the Slovenian claiming a 7-6 (7-5), 4-6, 6-4 victory.
Bedene will face Guido Pella next after the Argentine beat Taro Daniel 1-6, 6-3, 6-3.
Eighth seed Paire, who reached the third round of Wimbledon, suffered a 6-1, 6-3 defeat at the hands of Bulgarian Marton Fucsovics.
Fucsovics will take on qualifier Marco Trungelliti in the second round after the Argentine secured a 6-3, 6-4 win over Franko Skugor.
There was some good news for the seeds as the sixth-ranked Robin Haase from the Netherlands beat Brazilian Rogerio Dutra Silva 4-6, 7-5, 6-3 while ninth seed Maximilian Marterer beat local wild card Nino Serdarusic 3-6, 7-5, 6-3.
Teenager Felix Auger-Aliassime set up a clash against fellow NextGen player Andrey Rublev with a 6-3, 6-3 victory over Andrej Martin.