Ryan Harrison and Alex de Minaur both suffered defeats at the Hall of Fame Tennis Championships.
Stan Wawrinka's comeback was a short one, but three Americans advanced at the Italian Open.
This week marks a decade since Ryan Harrison joined a very exclusive ATP Tour club.
Defending champion Steve Johnson had his work cut out for him in Houston.
Denis Shapovalov is safely into the second round in Indian Wells, but Ryan Harrison crashed out.
Kevin Anderson and David Ferrer advanced at the Abierto Mexicano Telcel, but John Isner tumbled out.
The ATP have ruled that there was "no evidence" that Ryan Harrison racially abused Donald Young.
The ATP will probe "allegations of racial prejudice" after Donald Young-Ryan Harrison incident.
Things turned nasty between Donald Young and Ryan Harrison at the New York Open and continued on Twitter.